苦涩 发表于 2025-4-1 01:59:57
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FAT10,ts proteins to proteasomal degradation. The covalent linkage of ubiquitin or other ubiquitin-like modifiers (ULM) to specific substrates is achieved by adjoining them to target proteins with an enzyme cascade using three enzymes: E1, E2 and E3. The first enzyme activates the ULM, the second enzyme sConstrain 发表于 2025-4-1 12:44:04
https://doi.org/10.1007/978-1-4419-6676-6Conjugation; Deconjugation; Groettrup; Modifiers; Ubiquitin; enzymes; regulationhemophilia 发表于 2025-4-1 16:17:43
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Mineralogy and Elemental Composition,markably pleiotropic effects on cell function. These posttranslational modifications share a common mechanism comprised of three steps: an activating enzyme to couple ATP hydrolysis to formation of a high-energy intermediate at the carboxyl terminus of ubiquitin or the ubiquitin-like protein, a ligaaltruism 发表于 2025-4-2 02:41:41
http://reply.papertrans.cn/24/2356/235568/235568_66.png跳脱衣舞的人 发表于 2025-4-2 03:54:34
http://reply.papertrans.cn/24/2356/235568/235568_67.pngCarcinogenesis 发表于 2025-4-2 09:39:51
Chemical Composition of Source Waters,nzymes regulate cell biology by conjugating ubiquitin onto target proteins that are involved in a multitude of processes. In most cases this leads to degradation of the target, but in some cases CRL-dependent ubiquitination acts as a switch to activate or repress target function. The ubiquitin ligas