表范围
发表于 2025-3-21 16:10:46
书目名称Concepts, Mechanisms, and New Targets for Chemotherapy影响因子(影响力)<br> http://impactfactor.cn/2024/if/?ISSN=BK0234960<br><br> <br><br>书目名称Concepts, Mechanisms, and New Targets for Chemotherapy影响因子(影响力)学科排名<br> http://impactfactor.cn/2024/ifr/?ISSN=BK0234960<br><br> <br><br>书目名称Concepts, Mechanisms, and New Targets for Chemotherapy网络公开度<br> http://impactfactor.cn/2024/at/?ISSN=BK0234960<br><br> <br><br>书目名称Concepts, Mechanisms, and New Targets for Chemotherapy网络公开度学科排名<br> http://impactfactor.cn/2024/atr/?ISSN=BK0234960<br><br> <br><br>书目名称Concepts, Mechanisms, and New Targets for Chemotherapy被引频次<br> http://impactfactor.cn/2024/tc/?ISSN=BK0234960<br><br> <br><br>书目名称Concepts, Mechanisms, and New Targets for Chemotherapy被引频次学科排名<br> http://impactfactor.cn/2024/tcr/?ISSN=BK0234960<br><br> <br><br>书目名称Concepts, Mechanisms, and New Targets for Chemotherapy年度引用<br> http://impactfactor.cn/2024/ii/?ISSN=BK0234960<br><br> <br><br>书目名称Concepts, Mechanisms, and New Targets for Chemotherapy年度引用学科排名<br> http://impactfactor.cn/2024/iir/?ISSN=BK0234960<br><br> <br><br>书目名称Concepts, Mechanisms, and New Targets for Chemotherapy读者反馈<br> http://impactfactor.cn/2024/5y/?ISSN=BK0234960<br><br> <br><br>书目名称Concepts, Mechanisms, and New Targets for Chemotherapy读者反馈学科排名<br> http://impactfactor.cn/2024/5yr/?ISSN=BK0234960<br><br> <br><br>
冬眠
发表于 2025-3-21 22:01:53
Recent clinical advances with camptothecin analoguesn, demonstrated encouraging activity in early clinical testing but was abandoned due to unpredictable toxicity. In 1985, Hsaing and Liu observed that the cytotoxic effect of camptothecin requires the nuclear enzyme topoisomerase I . This finding coincided with the development of the semisynthetic
Delude
发表于 2025-3-22 02:35:13
The reversal of multidrug resistanceaboratory, tumor cells can be selected for resistance to a particular cytotoxin by repeated exposure to that drug. The selected cells often display crossresistance to a number of functionally and structurally distinct drugs. This drug-resistant phenotype is referred to as . (MDR). Currently, the bes
Implicit
发表于 2025-3-22 04:35:22
Fluoropyrimidine catabolismtes for important enzymatic reactions required in vital cell biologic processes, e.g., synthesis of DNA and RNA. Several reviews on the metabolism of antimetabolite drugs have recently been published, providing a general background on these drugs . The pyrimidine antimetabolite drugs consist of
使人入神
发表于 2025-3-22 09:11:24
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无价值
发表于 2025-3-22 14:19:18
Aspects of one-carbon folate cycling related to fluoropyrimidine and antifolate therapyxyuridylate (FdUMP) inhibition of thymidylate synthase (TS) occurs by the ordered, sequential binding of TS, FdUMP, and then 5-10-methylenetetrahydrofolate (CH.FH.) [.–.]. In cell-free kinetic systems, CH.FH. must be in excess for maximal TS-FdUMP-CH.FH. ternary complex formation and complete inhibi
无价值
发表于 2025-3-22 20:16:55
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多产子
发表于 2025-3-22 22:38:12
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吸引力
发表于 2025-3-23 03:43:41
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predict
发表于 2025-3-23 08:46:14
High-dose chemotherapy with peripheral blood progenitor autograftinglinic, this strategy also results in increased toxicity to normal tissues. For those cytotoxics that are primarily dose-limited by myelosuppression (e.g., alkylating agents, carboplain, and etoposide), the use of autologous bone marrow transplantation (ABMT) has facilitated substantial dose escalati