真实的人
发表于 2025-3-28 16:51:41
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Kinetic
发表于 2025-3-28 19:58:53
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圆桶
发表于 2025-3-28 23:14:22
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索赔
发表于 2025-3-29 04:08:25
Supply Management in der Hotelbranchections. As a result of the inclusion of evolutionary information, the sequences designed by EvoDesign have native-like folding and binding properties not seen by other physics-based design methods. In this chapter, we describe how EvoDesign can be used to redesign proteins with a focus on the comput
dainty
发表于 2025-3-29 07:54:54
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PAN
发表于 2025-3-29 11:35:50
Supply Management in der Hotelbranchegorithms to prospectively predict resistance mutations that arise in the active site of the dihydrofolate reductase enzyme from methicillin-resistant . (SaDHFR) in response to selective pressure from an experimental competitive inhibitor. We demonstrated that our top predicted candidates are indeed
长处
发表于 2025-3-29 15:47:02
Achievements and Challenges in Computational Protein Designotein regions, (4) identification of key hot-spot residues and the relative effect of remote regions, (5) assessment of shape-complementarity, electrostatics and solvation effects, (6) integration of thermal plasticity and functional dynamics, (7) negative design, (8) systematic integration of exper
通情达理
发表于 2025-3-29 22:29:50
Deterministic Search Methods for Computational Protein Designead-End-Elimination theorem combined with .* algorithm (DEE/.*), on Cost Function Networks algorithms (CFN), on Integer Linear Programming solvers (ILP) or on Markov Random Fields solvers (MRF). The way two of these methods (DEE/.* and CFN) can be used in practice to identify low-energy sequence-con
conception
发表于 2025-3-30 01:54:29
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Isthmus
发表于 2025-3-30 05:30:23
Multistate Computational Protein Design with Backbone Ensemblesstructure. In this chapter, we present a step-by-step guide to the implementation and analysis of MSD calculations with backbone ensembles. Specifically, we describe ensemble generation with the PertMin protocol, execution of MSD calculations for recapitulation of . protein G domain β1 mutant stabil