defray
发表于 2025-3-30 11:06:19
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Defraud
发表于 2025-3-30 15:40:07
Computational and Experimental Protocols to Study Cyclo-dihistidine Self- and Co-assembly: Minimaliinescence and their ability to self-encapsulate epirubicin, a chemotherapy drug. Here, we provide a detailed description of computational and experimental methodology for the study of cyclo-HH self- and co-assembling mechanisms, photoluminescence, and drug encapsulation properties. We outline the ex
Acquired
发表于 2025-3-30 17:53:50
Computational Tools and Strategies to Develop Peptide-Based Inhibitors of Protein-Protein Interacti severe diseases. Peptide derivatives are very promising therapeutic agents for modulating protein-protein associations with sizes and specificities between those of small compounds and antibodies. For the same reasons, rational design of peptide-based inhibitors naturally borrows and combines compu
放弃
发表于 2025-3-30 22:55:23
,Rapid Rational Design of Cyclic Peptides Mimicking Protein–Protein Interfaces,terfaces. The method selects cyclic peptides that structurally match backbone structures of short segments at a protein–protein interface. In a second step, the cyclic peptides act as templates for designed binders by adapting the amino acid side chains to the side chains found in the target complex
泄露
发表于 2025-3-31 01:16:45
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jet-lag
发表于 2025-3-31 06:05:42
Molecular Simulation of Stapled Peptides,cule drugs, and of designed antibodies. Because of their modest size, the rational design of such peptides is becoming increasingly amenable to computer simulation; multi-microsecond molecular dynamic (MD) simulations are now routinely possible on consumer-grade graphical processors (GPUs). Here, we
AUGUR
发表于 2025-3-31 11:35:58
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AVOID
发表于 2025-3-31 14:43:28
Computational Evolution Protocol for Peptide Design,y is describing accurately the peptide–target interactions at the molecular level. We here review a computational peptide design protocol whose key feature is the use of all-atom explicit solvent molecular dynamics for describing the different peptide–target complexes explored during the optimizatio
tangle
发表于 2025-3-31 21:07:40
Computational Design of Miniprotein Binders,onal antibodies, they can be designed to bind to therapeutic targets with high affinity, but they are more stable and easier to produce and to administer. In this chapter, we present a structure-based computational generic approach for miniprotein inhibitor design. Specifically, we describe step-by-
Ledger
发表于 2025-4-1 01:14:43
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