轻打
发表于 2025-3-28 17:07:07
Computational Design of RNA Parts, Devices, and Transcripts with Kinetic Folding Algorithms Implemenme- and dynamic aptazyme-regulated expression devices with quantitatively predictable functions (rREDs and aREDs, respectively) have been described (Carothers et al., Science 334:1716–1719, 2011). Here, we provide a detailed practical procedure for computational transcript design by illustrating a h
ECG769
发表于 2025-3-28 19:06:01
Kappa Rule-Based Modeling in Synthetic Biologycan model biological interactions both at the genetic and the protein–protein interaction level, resulting in detailed stochastic models accounting naturally for transcriptional and translational resource usage. We also hope to impart the intuitively modular nature of the modeling processes involved
Compatriot
发表于 2025-3-28 22:57:44
Chemical Master Equation Closure for Computer-Aided Synthetic Biology over 70 years. With the first complete solution of chemical master equations, a wide range of experimental observations of biomolecular interactions may be mathematically conceptualized. We anticipate that models based on the closure scheme described herein may assist in rationally designing synthe
commensurate
发表于 2025-3-29 04:16:25
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CT-angiography
发表于 2025-3-29 07:54:18
https://doi.org/10.1007/978-1-4842-6461-4thetic biology devices including biosensors, bioproduction, or regulation circuits. To that end, a rational workflow for computational protein design is described here consisting of (a) searching in the sequence, structure or chemical spaces for the desired function and associated protein templates;
GRUEL
发表于 2025-3-29 12:27:07
https://doi.org/10.1007/978-1-4842-6461-4urable mechanical devices. Of relevance to synthetic biology, DNA origami structures can be delivered to cells where they can perform complicated sense-and-act tasks, and can be used as scaffolds to organize enzymes for enhanced synthesis. The design of DNA origami structures is a complicated matter
吗啡
发表于 2025-3-29 19:01:15
https://doi.org/10.1007/978-1-4842-6461-4devices with predictable behaviors continues to increase. By combining engineered transcript components, such as ribosome binding sites, transcriptional terminators, ligand-binding aptamers, catalytic ribozymes, and aptamer-controlled ribozymes (aptazymes), gene expression in bacteria can be fine-tu
AWL
发表于 2025-3-29 22:25:49
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figurine
发表于 2025-3-30 02:01:05
https://doi.org/10.1007/978-3-658-29889-0h level of abstraction through constraints on otherwise unspecified DNA parts. The GEC compiler then selects parts which satisfy the constraints from a given parts database. GEC further provides more conventional programming language constructs for abstraction, e.g., through modularity. The GEC lang
instulate
发表于 2025-3-30 06:00:20
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