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Biosynthetic Studies on AntibioticsWe will pay selective attention to the data suggesting that repetitive administration may be associated with increased effects on a variety of parameters, and will not review data suggesting that cocaine may produce tolerance in some systems. While we will present our findings of the effects of repeIatrogenic 发表于 2025-3-25 23:10:06
Biosynthetic Studies on Antibioticsd significance of the amines involved in various stimulant effects of cocaine are still a controversial topic. Cocaine is a potent inhibitor of noradrenaline uptake (Hertting, Axelrod, and Whitby, 1961; Ross and Renyi, 1967; Langer and Enero, 1974; Azzaro, Ziance, and Rutledge, 1974), dopamine uptakLAP 发表于 2025-3-26 03:15:35
Mesolimbic and Extrapyramidal Sites for the Mediation of Stereotyped Behaviour Patterns and Hyperacs are in definitions and methodology. It is, therefore, our intention in this chapter to examine the literature related to the site of stimulant drug action in the brain, with particular reference to amphetamine and apomorphine and the stereotyped behaviour patterns and hyperactivity induced by thes路标 发表于 2025-3-26 06:34:57
Release of Neurotransmitters from the Brain , by Amphetamine, Methylphenidate and Cocaine, in the nerve terminals. On the other hand, the central stimulant actions of methylphenidate and cocaine are reduced by reserpine pretreatment but not by α-methyltyrosine (van Rossum, van der Schoot, and Hurkmans, 1962; Scheel-Krüger, 1971; Simon, Sultan, Chermat, and Boissier, 1972) suggesting thatechnic 发表于 2025-3-26 10:20:09
Distribution and Metabolism of Amphetamine in Tolerant Animals, of many processes are involved, including increased neurotransmitter synthesis, altered receptor sensitivity, and activation of inhibitory serotonergic pathways (Koda and Gibb, 1973; Mandell and Morgan, 1970; Sparber and Tilson, 1972).Breach 发表于 2025-3-26 14:38:41
Neurobiological Antagonism of Cocaine by Lithium,ody and nerve ending regions (median raphe and striate cortex, respectively) after hypotonic lysis of the preparations; and the overall rate of conversion of tryptophan to serotonin (5-HT) by synaptosomes. Our experimental methods have been described in detail elsewhere (Knapp et al., 1974; Knapp, MBlood-Vessels 发表于 2025-3-26 20:23:36
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