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Mechanisms in Irritant Contact Dermatitis,asis. Acute or repeated exposure to irritants determines the activation of the innate immune system with the release of pro-inflammatory cytokines and chemokines by keratinocytes and other skin resident cells. The local release of IL-1α, IL-1β, TNF-α and IL-6 activates endothelial cells and promotes转换 发表于 2025-3-27 10:21:24
Mechanisms in Allergic Contact Dermatitis,skin. In the sensitization phase, haptens activate the innate immune system by interacting with pattern recognition receptors, such as Toll like receptors, expressed by skin resident cells, thus initiating a cascade of events leading to the maturation and mobilization of skin dendritic cells. MaturiPreamble 发表于 2025-3-27 13:41:13
Histological, Immunohistochemical and Ultrastructural Aspects of Contact Dermatitis,he histological findings that best describe this type of dermatitis are spongiosis that eventually leads to the formation of vesicles and bullae, and a mild perivascular inflammatory infiltrate made of mononucleated cells. In chronic forms, acanthosis and hyper-parakeratosis of epidermis predominate征服 发表于 2025-3-27 18:27:17
Irritant Contact Dermatitis,cute toxic aggression, generally linked to a single strong etiological agent, or of repeated cumulative aggression by several weaker irritants. Contact irritation is mediated by a complex pathogenic mechanism, and the same substance can induce different clinical features depending on the concentratiFADE 发表于 2025-3-28 01:47:14
Allergic Contact Dermatitis,d at the site of exposure to the noxa and is accompanied by variable pruritus. It seems that some subjects are more prone to sensitization to environmental allergens than others, even if the total number of sensitized individuals in a population depends on the degree of skin exposure. The morphologi浮雕宝石 发表于 2025-3-28 04:25:25
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