insidious 发表于 2025-3-23 11:24:39
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The Interferon-Alpha Revival in CML,cludes immune activation and specific targeting of CML stem cells. Early studies of IFNα in CML demonstrated that it could induce extremely stable remissions, which correlated with long-term survival. Some patients even sustained their remission after discontinuing therapy, but the mechanism underly审问 发表于 2025-3-24 02:02:55
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Response-Related Predictors of Survival and of Treatment-Free Remission in CML,ical and cytogenetic response is still a desirable early measure of response. However measurement of the level of . transcripts in the blood by qRT-PCR, adjusted to the international scale (IS), is now the primary means of monitoring response. Achieving time-dependent molecular targets is a strong pMagnitude 发表于 2025-3-24 10:10:22
Discontinuation or Cessation of Tyrosine Kinase Inhibitor Treatment in Chronic Myeloid Leukemia Pats who respond to TKI is now considered very close to that of the healthy population control. Several clinical trials have demonstrated that some patients with CML in chronic phase who achieve sustained deep molecular remission (DMR) on TKI therapy can safely discontinue therapy and attempt treatment污秽 发表于 2025-3-24 12:47:29
2197-9766 nostic aspects and early response prediction.Examines the ch.This book provides state-of-the-art reviews of key issues and recent developments relating to chronic myeloid leukemia (CML), acquainting the reader with advances in research, treatment, and promotion of public health. Among the management肮脏 发表于 2025-3-24 15:36:44
Book 2021Latest editionwith advances in research, treatment, and promotion of public health. Among the management topics addressed are the choices, advantages, and pitfalls of first-, second-, and third-line treatments; the European LeukemiaNet recommendations; management of adverse effects of tyrosine kinase inhibitors (Customary 发表于 2025-3-24 19:28:52
https://doi.org/10.1007/978-3-663-11257-0 chronic phase of the disease. However, the mechanisms of resistance and disease progression are less well defined. In this chapter, we explore the various pathways involved in the pathogenesis of CML and also the biological events underpinning progression to the more advanced stages of the disease.Minatory 发表于 2025-3-24 23:54:47
https://doi.org/10.1007/978-3-658-20005-3-free remission (TFR). It should be considered a future criterion for evaluating a successful clinical trial that will account for quality of life and economic factors, important aspects to consider..The question of cure of CML is now one of the major concerns and must be considered in the management of the disease.