HILAR 发表于 2025-3-30 09:40:07
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Removal of Low-Density Lipoproteins by Alternative Pathwaysvel must either decrease the rate of LDL formation or speed up the rate of its clearance from the plasma. The latter can be effected by increasing the specific LDL (or apo B, E) receptor activity in the liver, as is actually brought about by administration of bile acid sequestrants and/or compactin or mevinolin .出处 发表于 2025-3-31 01:25:05
Receptors in the Regulation of Cholesterol Metabolism and specific amphipathic proteins (see for review). The latter, the apolipoproteins, not only are responsible for maintaining the structure of the particle but also act as recognition signals for cell membrane receptors which trigger lipoprotein endocytosis . The “classical” lipoprotein rece