AGGER
发表于 2025-3-27 00:26:31
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Adornment
发表于 2025-3-27 02:07:11
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AND
发表于 2025-3-27 06:21:02
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青少年
发表于 2025-3-27 13:07:14
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Introvert
发表于 2025-3-27 16:14:31
Chemogenomics Strategies for G-Protein Coupled Receptor Hit Finding,et and ligand clusters are linked by generating binding affinity profiles of chemotypes vs a target panel. The application of this multidimensional similarity paradigm will be described in the context of Lead Generation to identify novel chemical hit classes for G-protein coupled receptors.
高脚酒杯
发表于 2025-3-27 18:17:18
Chemogenomics Approaches to G-Protein Coupled Receptor Lead Finding,t screening (HTS) is often complemented by rational chemogenomics lead finding approaches. We have compiled a GPCR directed screening set by ligand-based virtual screening of our corporate compound database. This set of compounds is supplemented with novel libraries synthesized around proprietary sc
Conduit
发表于 2025-3-28 01:36:30
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沟通
发表于 2025-3-28 06:09:54
Probing Protein Function with Small Molecules, is providing the chemical means to understand biological systems not easily accessible using classical genetic manipulations. In this article, we will discuss how natural product mode of action studies and novel bio-organic manipulation of intracellular protein levels are proving useful in the expl
骨
发表于 2025-3-28 07:21:13
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prick-test
发表于 2025-3-28 11:20:28
Protein Structure Similarity Clustering and Natural Product Structure as Guiding Principles for Chetopology in the ligand-sensing cores of protein domains can be exploited for the design of small-molecule libraries in the development of inhibitors and ligands. Thus, a novel strategy of clustering protein domain cores based exclusively on structure similarity considerations (protein structure simi