craven
发表于 2025-3-26 21:06:53
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爱哭
发表于 2025-3-27 03:19:59
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Extort
发表于 2025-3-27 05:28:15
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NAUT
发表于 2025-3-27 11:56:13
https://doi.org/10.1007/b138932pacity to act as “backstage” sculptors of the epigenetic landscape by interacting with chromatin-modifying proteins and directing their activities. LncRNAs can thereby modulate locus-specific chromatin marks as well as arrange the three-dimensional configurations of entire chromosomes. They may also
Confirm
发表于 2025-3-27 16:36:18
https://doi.org/10.1007/b138932obstructive pulmonary disease (COPD) each year. Additionally, lung cancer is the most common cause of cancer death, causing over 1.5 million deaths per year. A promising direction for new therapies for these and other lung diseases, like asthma, comes from the notion that deranged intracellular sign
懦夫
发表于 2025-3-27 18:18:35
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Incompetent
发表于 2025-3-28 00:31:34
https://doi.org/10.1007/b138932scription factor binding, and recruiting chromatin-modifying enzymes. DNA methylation marks are introduced in both strands of DNA by DNA methyltransferases, allowing for heritable gene silencing. In addition to 5-methylcytosine, cells contain its oxidized forms 5-hydroxymethylcytosine, 5-formylcytos
乞讨
发表于 2025-3-28 05:58:00
Antonello MaiOffers a comprehensive review of the chemical mechanisms involved in epigenetics.Covers the significant findings about epigenetic targets.Explores the design, synthesis and biological validation of ep
睨视
发表于 2025-3-28 09:05:41
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heterodox
发表于 2025-3-28 12:47:40
Targeting the Zinc-Dependent Histone Deacetylases (HDACs) for Drug Discovery,ionally modified acyl-lysine residues back to lysine. At the epigenetic level, HDACs have a critical gene silencing effect, promoting the compaction of histone tails with DNA to prevent transcription. In addition, HDACs deacylate many nonhistone substrates in diverse cellular compartments to profoun