敏捷 发表于 2025-3-25 06:25:59
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Oliver Günther,Johannes Lambertsne caused significant neuronal death at days 1 and 3, and resulted in significant brain tissue loss at day 28. These results suggest that thrombin inhibition in the acute phase may reduce ICH-induced brain damage.pellagra 发表于 2025-3-25 16:15:57
Medullary Tractotomy for Facial Pain,of thrombin + tPA markedly increased Evans blue tissue content in ipsilateral brain samples (. < 0.05). Fluoro-Jade-stained sections from thrombin+ tPA group demonstrated significantly higher cell death counts (. < 0.01). Significant neurological deficit was revealed in thrombin+ tPA group in foreliInitiative 发表于 2025-3-25 22:03:16
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Bilirubin oxidation products, oxidative stress, and intracerebral hemorrhagealdehyde, and superoxide dismutase, indicating a potent oxidizing environment. BOX concentrations increased from 0.084 ± 0.01 in fresh blood to 22.24 ± 4.28 in hematoma at 72h, and were 11.22 ±1.90 in adjacent white matter (nmol/g). Similar chemical and analytical results are seen in ICH in vivo, inIndurate 发表于 2025-3-26 20:14:46
Deferoxamine reduces brain swelling in a rat model of hippocampal intracerebral hemorrhagen swelling (6.14 ± 0.45 vs. 7.11 ± 0.58mm. in the vehicle group, p<0.05). In addition, deferoxamine reduced hemoglobin-induced DNA damage. These results indicate that iron has a key role in hemoglobin-induced brain swelling. Deferoxamine may be a useful treatment for ICH patients.