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https://doi.org/10.1007/978-3-319-76783-3ed, the stem cell and the niche are subject to aging. Potent mechanisms of biological aging are control of cellular metabolism, the action of aging genes, epigenetic drift and inflammation, which also modulate the cellular age of stem cells. A common feature of aged stem cells is however hyperactiva博识 发表于 2025-3-29 06:19:31
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SpringerBriefs in Earth System Sciencesg, which occurs with each round of cell division, leads to a permanent proliferation arrest, also known as replicative senescence. This process has been shown to have important implications in vivo as an increase in the frequency of senescent cells occurs in mammalian tissue with age and in a varietcongenial 发表于 2025-3-29 13:57:30
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Palgrave Studies in Alternative Educationageing studies. In a sharp contrast to cancer cells, it is firmly regulated by cell cycle checkpoints that ensure evasion of stressed and genetically modified cells, limiting their expansion and serve as an innate check to carcinogenesis. Tumour suppressors and their regulatory proteins play key rol有危险 发表于 2025-3-29 21:53:54
Who Takes Part in Online Citizen Science?,Mitochondrial dysfunction is the principle cause of increased levels of reactive oxygen species (ROS) and oxidative stress, which is a key mediator of aging. The cell responds to this stressful stimulus by the induction of the cellular aging-stress response, cellular senescence. Here, we discuss theIntend 发表于 2025-3-30 00:07:22
https://doi.org/10.1007/978-3-319-77797-9cell, senescence can be one driving force of such diseases. In contrast, cancer is, on the one hand, associated with age as well, but can be seen as a gain of function disease. Cellular senescence can act to prevent cell proliferation and is believed to inhibit cancer growth. Interestingly, this tum思想流动 发表于 2025-3-30 07:34:38
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