WATER 发表于 2025-4-1 03:48:24
http://reply.papertrans.cn/23/2218/221779/221779_61.pngpersistence 发表于 2025-4-1 06:29:45
Digoxin Pharmacokinetics and Their Relation to Clinical Dosage Parameters,cal basis (Augsberger, 1951, 1954). It is particularly noteworthy that these calculations were performed without any knowledge of drug concentrations but by the use of analysis of clinical data on drug effects only; this is a rather modern approach.哀悼 发表于 2025-4-1 13:42:12
http://reply.papertrans.cn/23/2218/221779/221779_63.pngHiatal-Hernia 发表于 2025-4-1 15:52:06
A New Simple Assay for Determining Digoxin Serum Levels,r now). In the meantime, work on an enzyme immunoassay has been completed; therefore, we found it more appropriate to report on this assay, thus justifying the announcement of a new assay for determining digoxin levels. Because the ELISA will always be compared with the RIA, some information on the消散 发表于 2025-4-1 20:04:31
Chloroform-Extractable and Polar Metabolites Examined With Different Assays, A similar pattern of methyldigoxin was described by Rietbrock and Abshagen (1973) and Abshagen et al. (1974). The chemical nature of these polar metabolites were thought to be the sulfuric and glucuronic acid conjugates of the bis- and monoglycosides and of aglucone, as first proposed by Repke et aPAN 发表于 2025-4-2 02:23:22
http://reply.papertrans.cn/23/2218/221779/221779_66.pngHyperplasia 发表于 2025-4-2 05:15:57
Occurence and Chemical Nature of Polar Water-Soluble Digoxin Metabolites,etabolite fraction detectable in the urine, this phenomenon being first described in 1972 by Dwenger-Haberland (Dwenger and Haberland, 1972). The polar fraction in urine increases to a maximum 4 h after ingestion of the glycoside. At this time, half of the renally excreted amount is not extractable