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https://doi.org/10.1007/b138648ties, their electrophysiologic properties in the intact heart (where studies could determine thresholds of conduction), and their clinical use in specific syndromes. Most of these attempts did not increase our knowledge of antiarrhythmic drugs or their clinical application. Since quinidine, introducelectrolyte 发表于 2025-3-24 09:05:16
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Linear Partial Differential Equations,esults in impaired conduction velocity in myocardial tissue.. Overall clinical antiarrhythmic efficacy in this group is dependent upon the ability of these agents to alter conduction and refractoriness, and suppress diastolic depolarization, thereby interfering with reentrant circuits and suppressin精确 发表于 2025-3-24 18:15:46
Conservation Laws and Shock Waves,ysfunction can be identified as being at high risk for sudden cardiac death, protocols have been implemented to determine whether this endpoint can be eliminated. The group of antiarrhythmic agents, which are known as Vaughan Williams Class IC agents have demonstrated particularly unique clinical ch葡萄糖 发表于 2025-3-24 21:47:03
Linear Partial Differential Equations,lethal ventricular arrhythmias without hemodynamical 1 y significant symptoms1 the most appropriate endpoint of drug efficacy should be the prevention of sudden cardiac death. The pharmacological endpoint of significant statistical reduction in ventricular ectopic frequency, however, has been the mo铁砧 发表于 2025-3-24 23:37:10
Linear Partial Differential Equations,In addition to their pharmacologic property of prolonging myocardial repolarization they were all introduced for clinical use and study for indications unrelated to cardiac arrhythmias. Therefore, it is important to remember that their development was not guided by the intention to develop an ideal