FRET
发表于 2025-3-25 04:06:58
Discovery and Development of Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Dapagd selective .SGLT2 inhibitor with an EC. for .SGLT2 of 1.0 nM and 1,200-fold selectivity over .SGLT1. Dapagliflozin produced glucosuria in normal Sprague Dawley rats in a dose-dependent fashion. Moreover, a 0.1 mg/kg oral dose reduced blood glucose levels by as much as 55% in rats that had been made
柔软
发表于 2025-3-25 08:21:49
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observatory
发表于 2025-3-25 11:43:03
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legacy
发表于 2025-3-25 17:32:47
The Evolution of a Glycoconjugate Vaccine for ,,ake and processing of the antigen and resulted in a five-fold higher mannan-specific antibody response together with a cytokine profile appropriate for an antifungal vaccine. When the same trisaccharide was conjugated to a T-cell peptide derived from . cell-wall protein, the resulting glycopeptide–t
忙碌
发表于 2025-3-25 20:42:16
1862-2461 eractions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known 978-3-319-34537-6978-3-319-08675-0Series ISSN 1862-2461 Series E-ISSN 1862-247X
Spartan
发表于 2025-3-26 03:09:31
1862-2461in the field.Volumes are useful and of relevance for a longMedicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need fo
恫吓
发表于 2025-3-26 04:29:54
Klaus Wolf,Karin Breunig,Gerold Barthpossible target molecules. In a personal selection the authors demonstrate how to make use of carbohydrates as a starting point for Pd-catalyzed coupling reactions to obtain .-glycosides, how to link carbohydrate and cyclopropane chemistry, and how efficient carbopalladation cascades fuse carbohydrates with aromatic units.
invade
发表于 2025-3-26 10:12:38
Preparation of Total DNA from ,itfalls in docking of carbohydrates are described. Practical examples explain the use of docking methods for the rational design of carbohydrate-based inhibitors as well as the prediction of carbohydrate binding sites.
有毛就脱毛
发表于 2025-3-26 14:32:21
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在驾驶
发表于 2025-3-26 17:38:48
Computational Docking as a Tool for the Rational Design of Carbohydrate-Based Drugs,itfalls in docking of carbohydrates are described. Practical examples explain the use of docking methods for the rational design of carbohydrate-based inhibitors as well as the prediction of carbohydrate binding sites.