CRATE 发表于 2025-3-25 06:45:09
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TRPV1 in the Central Nervous System: Synaptic Plasticity, Function, and Pharmacological Implicationan effort to find a novel target to fight pain that is nonaddictive. However, in recent years, it was discovered that TRPV1 is also associated with a wide array of functions and behaviors in the central nervous system, such as fear, anxiety, stress, thermoregulation, pain, and, more recently, synapt开花期女 发表于 2025-3-25 15:33:42
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Capsaicin-Based Therapies for Pain Control,V1 antagonism has so far shown limited benefit in antinociception. Capsaicin, a TRPV1 agonist, has been shown to induce a refractory period in the nerve terminal expressing TRPV1 and even, in sufficient dosing, to create long-term nerve terminal defunctionalization. This has led to research into top极深 发表于 2025-3-25 21:57:38
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Capsaicin as an Anti-Obesity Drug,se tissue distribution between visceral and subcutaneous sites. Activation of the transient receptor potential vanilloid-1 channels by capsaicin prevents adipogenesis. A neurogenic mechanism modulates the regulation of fat metabolism by transient receptor potential vanilloid-1-sensitive sensory nervCholecystokinin 发表于 2025-3-26 08:10:44
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Capsaicin as New Orally Applicable Gastroprotective and Therapeutic Drug Alone or in Combination wiuman gastrointestinal physiology, pathology, and clinical pharmacology, and possible therapeutic approaches to enhance gastrointestinal mucosal defense in healthy human subjects and in patients with various different gastrointestinal disorders as well as its use with nonsteroidal anti-inflammatory d率直 发表于 2025-3-26 15:22:54
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Capsaicin for Osteoarthritis Pain,changes over time. Methods: Randomized controlled trials of topical capsaicin use in OA were identified from PubMed, EMBASE, and ISI Web of Knowledge. Effect on pain scores, patient global evaluation of treatment effectiveness and application site burning were assessed by standardised mean differenc