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Classical and Targeted Anticancer Drugs: An Appraisal of Mechanisms of Multidrug Resistance, for more than 30 years. The identification of P-glycoprotein (P-gp), a drug efflux transporter protein with affinity for multiple therapeutic drugs, provided an important potential mechanism and further work, which identified other members of ATP-binding cassette (ABC) family that act as drug transGAVEL 发表于 2025-4-1 17:02:22
In Vitro Methods for Studying the Mechanisms of Resistance to DNA-Damaging Therapeutic Drugs, mechanism that enables cancer cells to survive through eliminating the damaged DNA lesions and thereby developing resistance to DNA-damaging agents. This chapter describes the four experimental approaches for studying DDR and genotoxic drug resistance, including the use of γ-H2AX and comet assays t