Freeze
发表于 2025-3-25 03:23:25
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otic-capsule
发表于 2025-3-25 10:40:37
The Calcium-Sensing Receptor (CaR) and Human Disease,ed PTH secretion maintains the concentration of serum Ca.in humans within a narrow range (between 9.0 and 10.4 mg/dl). In several now well-described disorders resulting from alterations in the gene encoding the CaR (gene name CASR), this precise regulation of serum calcium concentration is disturbed.
Conclave
发表于 2025-3-25 12:59:37
Alternative Agonists and Modulators: Evidence that the Calcium-Sensing Receptor is a Multi-Modal Seimportant metabolic modalities, perhaps contributing to other biochemical feedback loops. Depending on the composition of the local extracellular ., the CaR can sense variations in extracellular levels of:
crescendo
发表于 2025-3-25 16:02:42
,Beschäftigungspolitik in Lateinamerika,riety of receptor-mediated events. The levels of free calcium in the cytosol (Ca..), although dependent to some extent on extracellular calcium (Ca..), are much lower than the latter (100 nM vs. 1.1–1.3 mM) (.,.). Quite unlike Ca.., Ca.. fluctuates rapidly and over a wide range (10-fold or more) in response to hormonal and other stimuli (.).
灌输
发表于 2025-3-25 22:48:23
https://doi.org/10.1007/978-3-322-97579-9re complex and multi-layered, with numerous opportunities for cross-talk between pathways. Furthermore, the predominant biological response to activation of the CaR is highly cell-type specific, implying that presence or absence of specific signaling intermediaries may have a profound effect on the outcome.
生气的边缘
发表于 2025-3-26 01:23:30
Terrorismus im Zeitalter der Globalisierung,ered at the glomerulus is usually reabsorbed in the proximal tubule (PT) with the remaining Ca. reabsorbed by the thick ascending limb of Henle’s loop (TAL) and more distal nephron segments (see figure 1 A). Sodium and calcium transport by the kidney generally occur in parallel such that there is a codependence of calcium and sodium transport (.).
不真
发表于 2025-3-26 07:33:21
An Overview of Extracellular Calcium Homeostasis and the Roles of the CaR in Parathyroid and C-celllogical processes. Intracellular calcium is vital for regulating myriad cellular functions, such as differentiation, secretion, proliferation and motility, and it also acts as a cofactor in numerous enzymatic reactions (.). Equally importantly, it serves as an intracellular second messenger for a va
调色板
发表于 2025-3-26 11:18:11
Structure-Function Relationship of the Extracellular Calcium-Sensing Receptor,R is expressed on the plasma membrane of a variety of cell types, including those involved in maintaining systemic calcium homeostasis, such as parathyroid chief cells, renal cells, as well as thyroid C-cells, and those not participating in systemic calcium homeostasis, such as brain and breast cell
Graphite
发表于 2025-3-26 12:54:50
Calcium Receptor-mediated Signaling,in coupled receptors (GPCR). Biological responses associated with activation of the CaR include regulation of hormone secretion, activation of ion channels, migration, proliferation, differentiation, and apoptosis. The mechanisms linking other G-protein coupled receptors to these diverse responses a
Perineum
发表于 2025-3-26 16:53:32
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