fiction 发表于 2025-3-26 21:30:30
The Therapeutic Utility of Targeting Cav2 Channels,and α.2.3, respectively; also known as α.,α. and α.). The use of selective peptide toxins has allowed the association of Ca.2.1, 2.2 and 2.3 with P- or Q-, N-, and B-type calcium currents, respectively (Catterall, 2000; Ertel et al., 2000; Jarvis and Zamponi, 2001). These currents are found almost e漂白 发表于 2025-3-27 01:54:46
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Pharmacology of Cav3 (T-Type) Channels,e 1984). Ca. entry through these channels serves to regulate intracellular processes such as contraction, secretion, neurotransmission, and gene expression, in response to action potentials and other membrane potential changes. Although all voltage-operated Ca. channels are activated by a conformatijocular 发表于 2025-3-27 16:46:26
Cellular Functions of Calcium Channel Subtypes,ase and cell migration. Voltage-activated calcium channels play a crucial role in severalof these processes (see Figure 1). Although the functional diversity of calcium channels can be explained by the rich molecular variety of this channel superfamily, a common denominator of calcium channel functicountenance 发表于 2025-3-27 19:02:05
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Modulation of High Voltage-Activated Calcium Channels by G Protein-Coupled Receptors,lead to calcium channel modulation. Agonist activation of the GPCR superfamily releases a G protein heterotrimer and promotes dissociation of a G protein α subunit from a G protein βγ heterodimer. Each of these components (Gα and Gβγ) regulates calcium channel activity. Gα mediates voltage-independecorporate 发表于 2025-3-28 09:23:18
Alternative Splicing in Voltage Gated Calcium Channels,age-gated calcium channel family. All major calcium channel subunits, Ca.α., Ca.β, and Ca.α.γ, are subject to alternative splicing. The structural changes generated by this form of RNA processing are often quite subtle but clearly critical for highly effective coupling to specific signaling pathwaysMendacious 发表于 2025-3-28 11:50:29
Book 2004vioralists studying animal models of human disease, and for pharmaceutical scientists interested in creating the next generation of calcium channel-targeted drugs. Several factors make an entire book on calcium channel pharmacology timely.