矿石 发表于 2025-3-26 21:19:39
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Integrin-Mediated Adhesion: Tipping the Balance between Chemosensitivity and Chemoresistance,mor progression and metastasis. Integrins cooperate with growth factor receptors to control many cellular functions including proliferation and cell survival. Integrin-mediated adhesion regulates many of the cell cycle checkpoints including activation of cyclin D/cdk4/6 complexes, expression of cyclsorbitol 发表于 2025-3-27 07:48:44
Insulin-Like Growth Factors and Breast Cancer Therapy,s or may have utility in combination with other agents. Population, preclinical, and basic data suggest the insulin-like growth factor (IGF) system functions to maintain the malignant phenotype in breast cancer. Since the IGFs act via transmembrane tyrosine kinase receptors, targeting of the key rec失眠症 发表于 2025-3-27 10:39:44
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Molecular Mechanisms of ErbB2-Mediated Breast Cancer Chemoresistance,. ErbB2 is a receptor tyrosine kinase with intrinsic tyrosine kinase activity. The mammalian EGFR family comprises four receptors (EGFR, ErbB2, ErbB3, and ErbB4), which are derived from a series of gene duplications early in vertebrate evolution and are 40%–45% identical.. ErbB2 is the only EGFR famSeminar 发表于 2025-3-27 18:17:09
Estrogen Receptors in Resistance to Hormone Therapy,unctional receptors. Thus, the ER is a major target for current and developing therapies. Although most ER-positive tumors initially respond to hormonal therapies such as tamoxifen, many tumors will eventually become resistant to tamoxifen induced growth inhibition. This chapter will discuss molecul课程 发表于 2025-3-28 01:50:14
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Breast Cancer Chemosensitivity978-0-387-74039-3Series ISSN 0065-2598 Series E-ISSN 2214-8019终端 发表于 2025-3-28 10:08:32
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