轻快走过
发表于 2025-3-25 03:52:12
https://doi.org/10.1007/978-3-540-71408-8d Manufacturing Practices (GMP). This chapter describes the self-assembling nanoparticle-based vaccines or synthetic vaccine particle (SVP) technology to induce antibodies against nicotine and potentially treat nicotine dependence.
错误
发表于 2025-3-25 08:02:33
Cocaine Hydrolases Designed from Butyrylcholinesterase
纵火
发表于 2025-3-25 12:31:39
Introduction: Biologics to Treat Substance Use Disorders: Vaccines, Monoclonal Antibodies, and Enzyn and Li 2012; Winchell et al. 2012; Donovan et al. 2012), low medication compliance during the conduct of clinical trials (Anderson et al. 2012, 2014; Somoza et al. 2013), and, with few exceptions, the perception by pharma that developing medications to treat SUDs will not provide a favorable retur
GEAR
发表于 2025-3-25 16:11:08
Therapeutic Vaccines for Treating Nicotine Addictionr the pharmacokinetics (PK) of nicotine, slowing and reducing its entry into the brain and attenuating its reinforcing effects by binding nicotine in the blood (Gorelick, Future Med Chem 4(2):227–243, 2012). Extensive preclinical and clinical research has been conducted on nicotine conjugate vaccine
Prologue
发表于 2025-3-25 22:16:54
Vaccines for Treating Cocaine Use Disordersbodies as catalysts for the metabolism of cocaine, researchers produced antibodies against the cocaine itself in human subjects..This cocaine vaccine now has been through late phase II clinical trials. The mechanism of action for this vaccine is to induce antibodies to the cocaine, which act kinetic
acetylcholine
发表于 2025-3-26 03:38:25
Vaccines for Opioid Addictionr slowing their distribution to the brain, and attenuating addiction-relevant behaviors including heroin self-administration and reinstatement. The antibodies elicited by vaccines directed at heroin and its metabolites do not appreciably cross-react with methadone, buprenorphine, or naltrexone and s
SCORE
发表于 2025-3-26 04:26:09
Cocaine and HIV Infection al. 2009), highlighting the extreme complexity of the overlapping epidemiologic landscape of cocaine use and HIV infection in the United States. The recent availability of the first prototypes of HIV and cocaine vaccines raises the question of the impact of these biological/medicinal interventions
流逝
发表于 2025-3-26 09:59:00
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一大群
发表于 2025-3-26 13:08:41
Enzyme-Based Cocaine Pharmacotherapies: Current Status and Projections for the Future make this enzyme useful for most cocaine abusers. Pharmacological and behavioral procedures for evaluation of compounds of interest exist at both the preclinical and clinical levels. Discovery technology is making great strides toward the development of long-lasting enzyme therapeutics.
Hippocampus
发表于 2025-3-26 19:13:34
Adenovirus-Based Vaccines for the Treatment of Substance Use Disorders vaccine platform using cocaine and nicotine targets. Summaries are provided of the supporting data for efficacy in mice, rats, and non-human primates with phenotypes that include drug biodistribution, drug-induced locomotor behavior, drug self-administration, and positron emission tomography of dru