Carter
发表于 2025-3-21 16:36:13
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Surgeon
发表于 2025-3-21 20:53:48
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Champion
发表于 2025-3-22 03:34:37
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Vital-Signs
发表于 2025-3-22 04:52:58
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anthesis
发表于 2025-3-22 10:34:25
Interspecies Extrapolationlation procedures will be exactly correct for all compounds and that when species-specific data are available, they should be used in risk assessment. In their absence, body weight or surface area extrapolations are used with the explicit knowledge that they are only approximately correct.
Impugn
发表于 2025-3-22 14:13:02
Comparative Carcinogenesis : Is There a Theoretical Approach to Inter-Species Similarity ?biological applications. By comparing the enunciation of the empirical problem with the suggested dimensional-analytical one,it appears that a scientific solution cannot be envisaged without a deep and novel study of the process of carcinogenesis get rid of current beliefs.
conspicuous
发表于 2025-3-22 20:00:01
The Role of Inhibited Intercellular Communication in Carcinogenesis: Implications for Risk Assessmennancial, technical) to perform the toxicological tests; and (d) imprecise ability due to species, genetic, developmental stage, sex and nutritional/occupational/environmental background, to extrapolate from short-term test or animal bioassay results to the unique individual human situation, put great uncertainties in any risk assessment process.
争吵
发表于 2025-3-23 00:54:11
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entreat
发表于 2025-3-23 04:02:32
ation (NATO) was held in Corfu, Greece in June, 1989. The intent of the workshop was to survey available pharmacokinetic and pharmacodynamic methods in cancer risk assessment and identify methodological gaps and research needs for biologically based methods in cancer risk assessment. Incorporation o
Generic-Drug
发表于 2025-3-23 08:05:52
From Alternating to Quasi-Alternating Links,the necessity to extrapolate experimental results (1) across species from mice or rats to humans, (2) from the high-dose regions to which animals are exposed in the laboratory to the low-dose regions to which humans are exposed in the environment, and (3) across routes of administration.