CODE 发表于 2025-3-30 12:05:14
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Biochemical Rationale for Selectivity in the Modulation of Methotrexate Activity During Leucovorin 6). This nucleoside circumvents the need for tetrahydrofolate cofactors by providing the end-product of tetrahydrofolate-dependent thymidylate synthesis. However, no clear biochemical rationale has been defined that could provide a basis for an inherent selectivity in the use of thymidine with metho小鹿 发表于 2025-3-30 22:09:21
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Biochemical Modulation of Anticancer Agents: Experimental and Clinical ApproachesProceedings of the 1Cursory 发表于 2025-3-31 09:24:06
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Biochemical Modulation of Anticancer Agents: An Overview,tivity against a given normal or tumor cell population are employed to . of an .anticancer agent. The modulation can be either to increase the cytotoxicity of the anticancer agent against clonogenic tumor cells or to decrease the cytotoxicity of the anticancer agent against cells of the dose-limitinMri485 发表于 2025-3-31 17:44:14
Biochemical Loci for Modulation of 5-Fluorouracil Activity,orouracil (FU) (1). This compound was soon found to possess significant antitumor activity in both mice (2) and men (3) and today FU and some of its derivatives, notably the deoxyribonucleoside 5-fluoro-2′-deoxyuridine (FdUrd), are extensively used in the treatment of metastatic cancers, singly or i