大气层
发表于 2025-3-23 10:34:31
Book 2019ajor pharmacological target. It covers all major areas of research in this field, from genetics, chemistry, in silico modeling, molecular biology to clinical applications, offering a cross-country view of the functional role of bile acids as signaling molecules, virtually acting on all major areas o
北极人
发表于 2025-3-23 15:00:57
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臆断
发表于 2025-3-23 19:55:30
UDCA, NorUDCA, and TUDCA in Liver Diseases: A Review of Their Mechanisms of Action and Clinical Approphilic BA (i.e., ursodeoxycholic acid, tauroursodeoxycholic, and, more recently, norursodeoxycholic acid), have been revamped. In the present review, we summarize current experimental and clinical data regarding these BAs and its role in the treatment of certain liver diseases.
转折点
发表于 2025-3-24 00:42:15
The Pharmacology of Bile Acids and Their Receptors,the liver from cholesterol and have been used for almost half a century for treating liver and biliary disorders. Since the early 1970s of the last century, chenodeoxycholic acid (CDCA), a primary bile acid, and ursodeoxycholic acid (UDCA), a secondary bile acid and the 7βepimer of CDCA, have been s
不能约
发表于 2025-3-24 06:05:01
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Redundant
发表于 2025-3-24 08:15:15
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国家明智
发表于 2025-3-24 13:48:22
The Enterokine Fibroblast Growth Factor 15/19 in Bile Acid Metabolism,dial hormone regulating glucose homeostasis, glycogen and protein synthesis, and primary bile acid (BA) metabolism. In the ileum, BA-dependent farnesoid X receptor (FXR) activation induces the production of FGF19, which reaches the liver through the portal system where it represses the expression of
MOAT
发表于 2025-3-24 15:04:54
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错事
发表于 2025-3-24 19:33:07
Structural Insight into the Binding Mode of FXR and GPBAR1 Modulators,and the G-protein bile acid receptor 1 (GPBAR1). These two receptors play a key role in many diseases related to lipid and glucose disorders, thus representing promising pharmacological targets. We pay particular attention to the chemical and structural features of the ligand-receptor interaction, p
繁殖
发表于 2025-3-25 02:36:02
Chemistry and Pharmacology of GPBAR1 and FXR Selective Agonists, Dual Agonists, and Antagonists,rgets for the treatment of several diseases, ranging from liver cholestatic disorders to metabolic syndrome, inflammatory states, nonalcoholic steatohepatitis (NASH), and diabetes..Consequently, the development of dual FXR/GPBAR1 agonists, as well as selective targeting of one of these receptors, is