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发表于 2025-3-30 08:27:59
Jillian G. Baker,Martin C. Michel,Roger J. SummersAdrenoceptors have been prototypes for rationale drug design and receptor structure and function.Adrenoceptors are target of guideline-recommended drugs for >30 diseases from heart to prostate.Most re
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发表于 2025-3-30 12:55:28
Handbook of Experimental Pharmacologyhttp://image.papertrans.cn/b/image/167135.jpg
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发表于 2025-3-30 21:51:20
https://doi.org/10.1007/978-3-7091-3214-2ne 2022) have been determined by X-ray crystallography and electron cryo-microscopy (cryo-EM) of all three βARs (β., β. and β.) and four out of six αARs (α., α., α., α.). The structures are in a number of different conformational states, including the inactive state bound to an antagonist, an interm
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发表于 2025-3-31 01:18:15
https://doi.org/10.1007/978-3-7091-3214-2ll nine corresponding adrenoceptor genes display genetic variation in their coding and adjacent non-coding genomic region. Coding variants, i.e., nucleotide exchanges within the transcribed and translated receptor sequence, may result in a difference in amino acid sequence thus altering receptor fun
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发表于 2025-3-31 05:48:25
https://doi.org/10.1007/978-3-662-36951-7are important therapeutic targets, over a century of effort has been put into developing drugs that modify their activity. This chapter provides an outline of how we have arrived at current knowledge of the receptors, their physiological roles and the methods used to develop ligands. Initial studies
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发表于 2025-3-31 09:36:19
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