无底
发表于 2025-3-26 23:05:24
https://doi.org/10.1007/978-3-658-31788-1h predicated on assumptions that autoimmune disease is triggered by foreign antigens recognized by B-cell receptors from diseased individuals, and that auto-antibodies are critical in the pathogenesis of autoimmune disease. However, both assumptions have been brought into question according to recent research findings.
REP
发表于 2025-3-27 04:56:03
https://doi.org/10.1007/978-3-642-52077-8d clinical, demonstrating that the kidney is an important site of injury in autoimmune disease. In systemic lupus erythematous, the prototypic autoimmune disorder, the kidney is the organ most commonly affected. By kidney biopsy, at least mild abnormalities are seen in all patients with lupus.
Ophthalmologist
发表于 2025-3-27 06:38:53
Diversity of Immunological Defects in Autoimmune Diseases,ts elaborated against foreign microbial constituents must also inevitably contact various self-constituents, thus rendering the latter vulnerable to destruction. The self-nonself discrimination problem for the immune system is compounded by the fact that the sequence of essential proteins is often highly conserved across the species.
hidebound
发表于 2025-3-27 10:43:47
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Terminal
发表于 2025-3-27 15:58:18
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Polydipsia
发表于 2025-3-27 20:23:54
Induction of Pathogenic Autoimmune T-Cell and Autoantibody Responses Through T-Cell Epitope Mimicryh predicated on assumptions that autoimmune disease is triggered by foreign antigens recognized by B-cell receptors from diseased individuals, and that auto-antibodies are critical in the pathogenesis of autoimmune disease. However, both assumptions have been brought into question according to recent research findings.
使腐烂
发表于 2025-3-28 01:25:11
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柏树
发表于 2025-3-28 03:09:26
Book 1999lf and other "self" systems. The authoritative experts writing here explore the mechanistic aspects of such autoimmune diseases as lupus, rheumatoid arthritis, diabetes, and autoimmune thyroid disease, and where possible delineate how malfunctioning immunological mechanisms can lead to clinical symp
座右铭
发表于 2025-3-28 06:18:44
https://doi.org/10.1007/978-3-658-31788-1ted from the repertoire. In the thymus, a process known as negative selection appears to result in deletion of T-cells bearing receptors with high affinity for self-antigens .. In the fetal liver and bone marrow, a similar process deletes the emerging B-cells bearing an Ig receptor specific for cellular antigens ..
vitrectomy
发表于 2025-3-28 11:51:18
https://doi.org/10.1007/978-3-476-99883-5tion in various tissues (along with other autoantibodies) initiates an inflammatory response that frequently leads to organ failure despite intensive immunosup-pressive therapy .. Nevertheless, the features that distinguish pathogenic from nonpathogenic autoantibodies have been the subject of considerable debate.