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Steroidogenesis and Enzymatic Conversions of Adrenal Steroid Hormones, A simplified scheme of adrenal steroidogenesis appears in Fig. 1. Each hydroxylation step is indicated and the newly added hydroxyl group is circled. The adrenocorticotropic hormone (ACTH) acts on the adrenals to increase the conversion of cholesterol to pregnenolone, the principal substrate for al