产生
发表于 2025-3-30 08:23:22
Food-Drug Interactions: Drug Development Considerations,trates a direct pharmacological interaction in which a meal component alters clinical response to oral drug administration dictating marketed product insert warnings and special prescription labeling.
不成比例
发表于 2025-3-30 14:43:10
Drug-Drug Interactions,s in drug exposure and to clinically significant QT prolongation or, in some cases, serious arrhythmias. Mibefradil, also a CYP3A4 substrate, is a potent inhibitor of CYP3A4 and P-gp transporter. Concomitant administration of mibefradil with other CYP3A4 and P-gp substrates can lead to increased adv
infringe
发表于 2025-3-30 19:45:04
Role of Preclinical Metabolism and Pharmacokinetics in The Development of Celecoxib,s that target COX-2 relative to COX-1.brought into clinical use new drugs that obviated the toxicological limitations of older NSAIDs. Celecoxib (Celebrex.), the first drug approved based on this COX-2 selectivity, entered clinical use in 1999. In the context of this chapter, COX-2-selective refers
crescendo
发表于 2025-3-31 00:40:13
Efficient and Effective Drug Development,that is changing every day. Research commitments are complicated by a limited but growing understanding of disease processes as well as the spread of new afflictions such as AIDS, West Nile Fever, etc. to larger and larger populations. In addition, improved medical treatments of disease have resulte
CLOT
发表于 2025-3-31 02:20:47
Bioanalytical Methods: Challenges and Opportunities in Drug Development,es has been evolving for decades. The uninterrupted introduction of new technologies and the increasing attention being paid by global regulatory authorities to validation issues has continued to shape this scientific field. However, in the last five years, there has been an unprecedented increase b