Chandelier 发表于 2025-3-25 04:25:54
The interaction of transport mechanisms and intracellular enzymes in metabolizing systemsivity of these intracellular enzymes, it is unlikely that either COMT or MAO is ever saturated in vivo. However, in vitro saturation of extraneuronal COMT and MAO reveals that extraneuronal COMT is a high-affinity, but extraneuronal MAO a low-affinity enzyme. Hence, membrane-bound COMT appears to beAlcove 发表于 2025-3-25 08:41:34
The mechanism of action of antidepressants revisedmore selective antidepressants led to new reflections upon the mechanism of action. On the level of transmitters, α.upregulation, increased activity of the dopaminergic system, an alteration in the balance between the different transmitter systems, are reported and seem to be important. Most promisi有偏见 发表于 2025-3-25 13:14:54
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,Die rechtliche Identität Gesamttirols,ivity of these intracellular enzymes, it is unlikely that either COMT or MAO is ever saturated in vivo. However, in vitro saturation of extraneuronal COMT and MAO reveals that extraneuronal COMT is a high-affinity, but extraneuronal MAO a low-affinity enzyme. Hence, membrane-bound COMT appears to be发现 发表于 2025-3-25 23:44:04
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https://doi.org/10.1007/978-3-658-34957-8/day, both analogues produced greater inhibition of MAO-A and -B than did tranylcypromine. 4-Methoxytranylcypromine and 4-fluorotranylcypromine were similar in their extent of inhibition of MAO-B but the former was more potent than the latter at inhibition MAO-A.chronicle 发表于 2025-3-26 06:55:22
http://reply.papertrans.cn/16/1547/154675/154675_27.pngMast-Cell 发表于 2025-3-26 09:20:01
http://reply.papertrans.cn/16/1547/154675/154675_28.png王得到 发表于 2025-3-26 15:35:39
http://reply.papertrans.cn/16/1547/154675/154675_29.pngGrating 发表于 2025-3-26 18:25:49
The expression of human MAO-A and B genes and adult brains. The tissue distribution of these transcripts was determined. Small intestine and placenta express, in addition to the MAO-A 5Kb transcript, a 2Kb transcript determined to lack a 3′ flanking region. MAO-A appeared prior to MAO-B in the fetal brain, whereas both MAO-A and B were fou