脱离 发表于 2025-3-30 08:29:44
http://reply.papertrans.cn/16/1543/154273/154273_51.pngCharade 发表于 2025-3-30 14:41:46
http://reply.papertrans.cn/16/1543/154273/154273_52.pngfrozen-shoulder 发表于 2025-3-30 17:36:38
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https://doi.org/10.1007/978-3-662-34627-3 that the targeting of newly synthesized membrane proteins is governed largely by a ubiquitously distributed set of cytoplasmic domain sorting signals. These determinants may be superficially related to well-characterized signals for localization at plasma membrane-coated pits. Their inactivation reAdj异类的 发表于 2025-3-31 02:56:34
http://reply.papertrans.cn/16/1543/154273/154273_55.png有说服力 发表于 2025-3-31 07:59:06
https://doi.org/10.1007/978-3-662-34626-6protein (APP) located at chromosome 21q21.2. Mutations in APP have also been found in families segregating hemorrhagic stroke due to congophilic .A4 amyloid angiopathy (CAA) both in the presence and absence of AD. These mutations are located close to known proteolytic cleavage sites in APP, either a可以任性 发表于 2025-3-31 12:34:53
http://reply.papertrans.cn/16/1543/154273/154273_57.pngMeager 发表于 2025-3-31 14:23:00
https://doi.org/10.1007/978-3-531-90487-0larger transmembrane glycoprotein which can be subject to several cleavage events and secreted. The predominant processing pathway cleaves APP within the .A4 peptide sequence, while other events can result in minor quantities of .A4. Thus it is believed that the accumulation of .A4 results from oneCholagogue 发表于 2025-3-31 21:25:32
http://reply.papertrans.cn/16/1543/154273/154273_59.pnginstill 发表于 2025-3-31 21:54:46
https://doi.org/10.1007/978-3-531-90487-0s, growth factor-stimulated protein kinases that phosphorylate and thereby modulate the properties of many proteins that have key regulatory functions. These include other protein kinases, transcription factors, membrane enzymes, and cytoskeletal proteins (e.g., tau, MAP2). This wide array of phosph