粗鲁的人
发表于 2025-3-25 04:26:59
Jaroslav Smítal,Marta Štefánková barrier to lifestyle modifications, genetic counseling, and specific treatment. Targeted screening allows for high detection rates and lower costs than population screening. Little is known about the prevalence and demographic and clinical characteristics of individuals with the main AATD genotypes
AMOR
发表于 2025-3-25 08:08:11
Ashwini Jadhav,Sankunny Mohan Karuppayil emphysema and/or bronchiectasis (Silverman and Sandhaus, N Engl J Med 360(26):2749–57, 2009). It also represents the most common reason that an adult is tested for AATD (The Alpha 1-Antitrypsin Deficiency Registry Study Group, Chest 106(4):1223–32, 1994). This bias toward testing individuals with l
SEEK
发表于 2025-3-25 14:35:38
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秘密会议
发表于 2025-3-25 17:43:50
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抗原
发表于 2025-3-25 21:40:21
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Agnosia
发表于 2025-3-26 01:19:38
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figure
发表于 2025-3-26 08:08:34
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珊瑚
发表于 2025-3-26 10:36:18
Alpha-1-Antitrypsin and the Serpins,ease can result in both loss-of-function and gain-of-function disabilities. In biology, α-1-antitrypsin is the archetype of an extensive superfamily of serine proteinase inhibitors, the serpins, which control essential intra- and extracellular functions. A central feature of the serpins is their ext
聪明
发表于 2025-3-26 12:51:43
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Obvious
发表于 2025-3-26 20:27:13
Misfolding and Polymerisation of Alpha1-Antitrypsin: Conformational Pathology and Therapeutic Targe such as the common Z (Glu342Lys) variant vulnerable to misfolding and polymerisation that underlie the disease mechanisms of α1 -antitrypsin deficiency. Combinations of gain- and loss-of-function effects explain the observed disease behaviour. Detailed studies of these processes lead to hypotheses