包裹
发表于 2025-3-26 23:02:33
Selective Binding of Linear Ubiquitin Chains to NEMO in NF-kappaB Activationan acute stimulation of cells with variety of cytokines leads to Lys63-linked ubiquitin chain conjugation on the receptor-associated complexes to activate the TAK1 kinase. In addition, function of the linear ubiquitin chain assembly (LUBAC) ligase is required for the activation of IkappaB kinase com
拱形大桥
发表于 2025-3-27 01:21:55
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慢慢啃
发表于 2025-3-27 09:01:41
Temporal Control of TNFα Signaling by Miz1apoptosis, and tumorigenesis mainly through its cytoplasm membrane receptor TNF-R1 complex 1 , which activates downstream effectors such as NF-κB, caspases and JNK. However, the control of TNF-R1 complex 1 activity is incompletely understood. We report here that the transcription factor zinc fi
aspect
发表于 2025-3-27 12:48:09
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Integrate
发表于 2025-3-27 16:11:14
The Edar Subfamily in Hair and Exocrine Gland Developmentnown about the physiological role of Troy and Xedar. Research on the Edar pathway has focused on hair follicle and tooth biology, but recent progress has been made in uncovering its relevance in morphogenesis of glandular appendages as well.
Pelago
发表于 2025-3-27 20:56:19
High Endothelial Venule Reporter Mice to Probe Regulation of Lymph Node Vasculatureice express the reporter gene in HEVs in concurrence with the endogenous gene and PNAd. Additional mice transgenic for lymphatic vessel reporter constructs are in development. These will provide material for in vivo imaging and allow us to evaluate the regulation and interaction of HEVs and LVs.
付出
发表于 2025-3-27 23:23:08
Eiger and Wengen: The , Orthologs of TNF/TNFRs with a C-terminal TNF homology domain and a hydrophobic transmembrane domain. The sequence of the Eiger’s TNF domain shows highest homology with human EDA-A2 (28%) and also shows significant homology with all known mammalian TNF superfamily members.
贪心
发表于 2025-3-28 02:47:54
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HARP
发表于 2025-3-28 07:39:31
New Perspectives in TNF-R1-Induced NF-,B Signalingcess has been unclear. We summarize a recent study from our lab defining the roles of TRAF2 and cIAP1 s in activation of NF-κB downstream of TNF-R1 and report the surprising finding that RIPK1 is not essential for TNF-R1-induced NF-κB. Alternative mechanisms of how NF-κB may be activated by TNF-R1 in the light of these findings are discussed.
FECT
发表于 2025-3-28 12:20:56
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