感情脆弱 发表于 2025-3-28 17:53:54
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Leo Dorst,Chris Doran,Joan Lasenbygnal sequence, but lacks a hydrophobic signal sequence at its carboxyl terminus, suggesting that the protein is destined for export. Consistent with the surface localization of the GPI-linked transferases, multiple surface substrates have been identified in myotubes and activated lymphocytes, and, nKaleidoscope 发表于 2025-3-29 03:16:05
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https://doi.org/10.1007/978-1-4612-0089-5lls. Taken together these data strongly support the notion that benzamides and nicotinamides have potent anti-inflammatory and antitumor properties, because their primary mechanism of action is regulated by inhibition at the gene transcription level of NF-kB, which in turn inhibits TNF. and inducesJAMB 发表于 2025-3-29 12:51:20
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https://doi.org/10.1007/978-1-0716-2301-5yme that catalyzes the synthesis of protein-bound ADP-ribose polymers in eucaryotic chromatin. A detailed kinetic analysis of the automodification reaction of PARP in the presence of nicked dsDNA indicates that protein-poly(ADP-ribosyl)ation probably occurs via a sequential mechanism since enzyme-bo