Hypothesis 发表于 2025-3-21 19:41:33
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Alan Shipman important in development and in a number of pathological conditions including cancer and autoimmune diseases. Many transcription factors have been shown to regulate apoptosis in a range of biological systems. However, the downstream target genes and the mechanism of their action have not been clear首创精神 发表于 2025-3-22 07:19:33
Alan Shipmann diseases (Thompson, 1995). Apoptosis can be distinguished from the other major form of cell death, necrosis, on the basis of both morphological and biochemical features; these include chromatin condensation with nuclear pyknosis, and cytoplasmic shrinkage (Thompson, 1995). One prominent hallmark o随意 发表于 2025-3-22 09:14:34
Alan Shipmanfar more complex picture, in which apoptotic and necrotic phenotypes might present simultaneously (.). For example, TUNEL positivity in cardiomyocytes does not necessarily entail the presence of cell death that has an apoptotic phenotype (.). Complicating the matter further is the promiscuous use ofindignant 发表于 2025-3-22 16:39:57
Alan Shipmanhe expression levels of these elements can be assessed by immunohistochemistry (IHC) and can indicate general trends in pro- versus anti-apoptotic tendencies of the cells. IHC is particularly useful when studying large cohorts of paraffin-embedded specimens. Advances in tissue microarray (TMA) techn有特色 发表于 2025-3-22 20:16:09
Alan Shipmanls. It was previously considered a humble garbage collector, performing housekeeping duties to remove misfolded or spent proteins. Recent findings also substantiate a pivotal role of the proteasome in the regulation of apoptosis. Polyubiquitin conjugation of key pro-and antiapoptotic molecules targeIRS 发表于 2025-3-22 21:24:46
Alan Shipmansses. The best characterized of these are lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P), which have both emerged as important regulators of cell growth and survival. Identification of LPA and S1P receptors in the past several years has led to the accumulation of evidence that most ce逗它小傻瓜 发表于 2025-3-23 02:16:56
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Alan Shipmanrespect of Germany, France and Italy. Rumours of imminent German aggression were largely responsible. Urgent answers were needed to two hypothetical questions, the kind which politicians publicly disclaim any obligation to answer. The hypothesis was that the rumours were true and that Hitler intende