招待 发表于 2025-3-28 15:12:25
http://reply.papertrans.cn/103/10204/1020326/1020326_41.pngBridle 发表于 2025-3-28 22:09:33
Molecular Pathways in Growth and Survival: Epigenomicsetic markers is histone acetylation which has been shown to be deregulated in clonal disorders, including both solid tumors and B-cell malignancies, such as Waldenstrom’s Macroglobulinemia (WM). Importantly, recent evidences have suggested that WM cells present with an aberrant histone acetylation s微不足道 发表于 2025-3-29 00:11:26
The Bone Marrow Microenvironment and Tumor Cells Interactions in Waldenström’s Macroglobulinemia(BM) is always involved and infiltrated by the monoclonal lymphoplasmacytic cells. Within the BM microenvironment WM cells thrive and produce IgM. BM microenvironment plays a critical role in the progression of the disease from the stage of MGUS to asymptomatic and symptomatic WM, and a permissive B发酵 发表于 2025-3-29 04:42:24
Waldenstrom’s Macroglobulinaemia: Immunosurveillance and the Immune Micro-environmentnaemia (WM), there are measurable changes in the immune system with abnormalities of T-cells, NK cells and the ability to respond to external immunological stimuli. The homeostatic balance between the activation and suppression of immune antitumour effector cells in vivo is controlled by a network o移植 发表于 2025-3-29 10:05:16
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Genetic Predisposition to Waldenström MacroglobulinemiaGUS recognized as a precursor condition for WM. Following early observations of clustering of WM (and IgM-MGUS) in families, several lines of evidence have developed that support the hypothesis of a genetic component of WM susceptibility. Family studies have provided seminal observations in delineatCUB 发表于 2025-3-29 19:00:54
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